Associate Professor Simon Barry I am a molecular biologist studying the basis of immunological defects giving rise to autoimmune diseases such as type 1 diabetes.
I am interested in regulatory T cells ( the policemen of the immune system), aiming to understand what genes drive their formation and their normal function with a view to developing novel cell and drug based therapies and diagnostic biomarkers. Specifically I wish to identify how the transcription factor FOXP3 regulates genes in the immune system, and I have also begun to investigate its role as a tumour suppressor. It is apparent that the molecular mimicry of tolerance mechanisms is a means by which solid tumours may evade immune detection. This reinforces the observation that tissues and systems strongly interact, and that global gene regulation plays a key role in disease progression. 21. Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew Goodall Y and Goodall GJ: The microRNA 200 family and miR 205 regulate epithelial mesenchymal transition by targeting the E cadherin repressors, ZEB1 and SIP1. Nature Cell Biology 2009 10 (5)593 601 IF = 18.1,  JRK5/156 22. Hutton JF, Gargett T, Sadlon TJ, Bresatz S, Brown CY, Zola H, Shannon MF, D'Andrea RJ, Barry SC, Development of CD4+CD25+FOXP3+ Regulatory T cells from Cord Blood Haemopoietic Progenitor Cells. Journal of Leukocyte Biology 2009 vol. 85 no. 3 445 451 IF = 4.3, JRK50/156 23. Li S, Floess S, Hamann A, Gaudieri S, Lucas A, Hellard M, Roberts S, Paukovic G, Plebanski M, Loveland BE, Aitken C, Barry S, Schofield L, Gowans EJ. Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection. PLoS Pathog. 2009 Dec;5(12) 24. Nicola Leung, Nicholas Mabarrack, Angela Barbour, Adrian Cummins and Simon C Barry. Foxp3+ Regulatory T Cells, Th17 Effector Cells and Cytokine Environment in Inflammatory Bowel Disease. Cheryl Y. Brown, Timothy Sadlon, Tessa Gargett, Elizabeth Melville, Rui Zhang, Yvette Drabsch, Craig A. Strathdee, Thomas J. Gonda, Simon C. Barry Robust, reversible gene knockdown using a single lentiviral shRNA vector Hum Gene Ther. 2010 30 1 80 89. 26. Sadlon TS, Wilkinson BG, Pederson S, Brown CY, Bresatz S, Gargett T, Melville E, Peng K, Glonek G, Goodall oakley lens replacement GJ, Zola H, Shannon MF, Barry SC. Genome wide identification of human FOXP3 target genes in natural regulatory T cells J Immunol. 2010 Jul 15;185(2):1071 81. Epub 2010 Jun 16. 27. Beyer M, Classen S, Lahl K, Thabet Y, Riley JL, Sadlon TJ, Sch E, Flach A, M R, Basu S, Inhester T, Ciesla M, Gaarz A, Eggle D, Debey Pascher S, End E, Knolle PA, Hippen KL, Blazar BR, Balderas R, Waha A, June CH, Quast T, Kolanus W, Schermer B, C Barry SC Sparwasser T, Schultze JL FOXP3 dependent repression of SATB1 ensures regulatory T cell commitment Nature Immunology 2011 Aug 14;12(9):898 oakley luxottica 907. 28. Dubravka, Ranall, Max V., Wilson, Benjamin M., Leo, Paul, Purdon, Amy S., Hyde, Carolyn, Nourbakhsh, Ehsan, Grimmond, Sean M., Barry, Simon C., Gabrielli, Brian and Gonda, Thomas J. (2011) A high throughput platform for lentiviral overexpression screening of the human ORFeome. PLoS One, 6 5: e20057.1 e20057.14 29. McInnes N, Sadlon TJ, Brown CY, Pederson S, Beyer M, Schultze JL, McColl S, Goodall GJ, Barry SC FOXP3 and FOXP3 regulated microRNAs suppress SATB1 in breast cancer cells. Oncogene. 2011 Jul 11. doi: 10.1038/onc.2011.293 30. Roberts Thomson IC, Fon J, Uylaki W, Cummins AG, Barry SC Cells, cytokines and inflammatory bowel disease: a clinical perspective. Expert Rev Gastroenterol Hepatol. 2011 Dec;5(6):703 16. 31. Nicholson IC, Mavrangelos C, Bird DR, Bresatz Atkins S, Eastaff Leung NG, Grose RH, Gundsambuu B, Hill D, Millard DJ, Sadlon TJ, To S, Zola H, Barry SC, Krumbiegel D. PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20. Cell Immunol. 2012 Jan;275(1 2):12 8. 32. D Hill, N Eastaff Leung, SBresatz Atkins, N Warner, J Ruitenberg, D Krumbiegel, S Pederson, N McInnes, C Y. Brown, T Sadlon, oakley zero S C Barry. Inhibition of activation induced CD154 expression on human CD4+ CD25 cells accurately reports suppressor function by human nTreg, iTreg and regulatory T cell lines.2012 Immunology and Cell Biology (2012) 90, 812 821 33. Grose RH, Millard DJ, Mavrangelos C, Barry SC, Zola H, Nicholson IC, Cham W T, Boros C, Krumbiegel D. Comparison of blood and synovial fluid Th17 and novel PI16 Treg cell subsets in juvenile idiopathic arthritis J Rheumatol 39.10 (2012): 2021 2031. 34. Penno MA, Couper JJ, Craig ME, Colman PG, Rawlinson WD, Cotterill AM, Jones TW, Harrison LC and ENDIA Study Group: Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at risk where to buy oakley eyeglasses of type 1 diabetes. BMC Pediatrics 2013, 13:124. 35.
Jolley L, Holman C, Ruben J BarrySC, Gecz J. The UPF3B Gene, Implicated in Intellectual Disability, Autism, ADHD and Childhood Onset Schizophrenia Regulates Neural Progenitor Cell Behaviour and Neuronal Outgrowth. Human Molecular genetics In Press External reviewer: Journal of Immunology, Blood, Human Gene Therapy, Gene Therapy, Molecular Therapy, Journal of Cellular and Molecular Medicine, Journal of Leukocyte Biology, Journal of Immunological Methods.
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